I know what you are thinking, not another space adventure game. There are plenty of those already, and they are way cooler when you have alien technology and weapons. This game would stray away from that format. It would be a mix between and awesome flight simulator and Myst.
Also, depending on what puzzles you were able to solve during training you would have different tools to help you once you are on the mission. You can be a scientist, engineer, or pilot. Each has benefits and skills that will help you solve different problems on the space craft. Once you get to the moon, that is where the game takes a turn from reality, and you learn that the moon used to support alien life. You find and underground temple, and learn a back story. The actions you take will give you several different endings.
In the end your goal would be to go home. What would ad to this games aura is if the technology and music in the game were from the 1960's. That could add a creepy retro feel to the game. Ultimately, just as with Myst, the storyline would have to be really good, and this would be a largely puzzle solving game. It would even make a good Iphone app.